GensearchHIV

GensearchHIV is a DNA sequence analysis software dedicated to prediction of HIV resistance using the French public ANRS algorithm.

GensearchHIV has been developed in close collaboration with the HIV laboratory of the French University Hospital CHU Bichat, Paris. It allows to analyse DNA sequences from HIV-1 (rt, prot, gp41hr1, gp120, integrase) and HIV-2 (protA, protB, rtA, rtB) and interprets the detected mutations according to the latest algorithms published by the ANRS.

GensearchHIV is not linked to any manufacturer's chemicals or primers: the user is free to select his supplier and use the proposed procedures of the ANRS.

GensearchHIV also links to public online interpretation tools to help identify the subtype as well as its tropism (see our Links section to access these public tools
We have also published a first demo video which quickly goes through the process of analysis, interpretation and storage of the result of a DNA analysis, you can find the video in the Tutorials section of our website.

Some publications:

High level of APOBEC3F/3G editing in HIV-2 DNA vif and pol sequences from antiretroviral-naive patients.
Authors: Bertine, M., Charpentier, C., Visseaux, B., Storto, A., Collin, G., Larrouy, L., ... & ANRS CO5 HIV-2 Cohort
Publication: AIDS, 2015, vol. 29, no 7, p. 779-784.

Concordance between HIV-2 genotypic coreceptor tropism predictions based on plasma RNA and proviral DNA
Authors: Visseaux, Benoit; Charpentier, Charlotte; Taieb, Audrey; Damond, Florence; Bénard, Antoine; Larrouy, Lucile; Chêne, Geneviève; Brun-Vézinet, Françoise; Matheron, Sophie; Descamps, Diane; the ANRS CO5 HIV-2 Cohort
AIDS:14 January 2013 - Volume 27 - Issue 2 - p 292–295 doi: 10.1097/QAD.0b013e32835b8bbd Research Letters

Prevalence of subtype-related polymorphisms associated with in vitro resistance to attachment inhibitor BMS-626529 in HIV-1 ‘non-B’-infected patients
Authors: Charlotte Charpentier, Lucile Larrouy, Benoit Visseaux, Roland Landman, Marine Levittas, Alexandre Storto, Florence Damond, Yazdan Yazdanpanah, Patrick Yeni, Françoise Brun-Vézinet and Diane Descamps
J. Antimicrob. Chemother. (2012) doi: 10.1093/jac/dks067

Molecular Determinants of HIV-2 R5–X4 Tropism in the V3 Loop: Development of a New Genotypic Tool
Authors: Benoit Visseaux, Margarita Hurtado-Nedelec, Charlotte Charpentier, Gilles Collin, Alexandre Storto, Sophie Matheron, Lucile Larrouy, Florence Damond, Françoise Brun-Vézinet, Diane Descamps and the ANRS CO 05 HIV-2 Cohort
J Infect Dis. (2012) 205 (1): 111-120. doi: 10.1093/infdis/jir698

Raltegravir genetic resistance patterns in HIV‑2 patients failing raltegravir containing regimen
Authors: B Roquebert, S Matheron, A Bénard, J. Leleu, R Tubiana, M Karmochkine, G Chêne, F Damond, F Brun-Vézinet, D Descamps and the French ANRS HIV-2 Cohort (ANRS CO 05 VIH-2).
17th Conference on Retroviruses and Opportunistic Infections. San Francisco, USA (pp. 16-19).

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